Line 45:
Line 45: [[Category:Tetracyclic antidepressants]]
[[Category:Tetracyclic antidepressants]]
[[Category:Tricyclic antidepressants]]
[[Category:Tricyclic antidepressants]]
<gallery>
File:Amoxapine.svg|Amoxapine chemical structure
File:Amoxapine_ball-and-stick_model.png|Amoxapine ball-and-stick model
File:Amoxapine.svg|Amoxapine chemical structure
File:7-Hydroxyamoxapine.svg|7-Hydroxyamoxapine chemical structure
File:8-Hydroxyamoxapine.svg|8-Hydroxyamoxapine chemical structure
</gallery>
Amoxapine Amoxapine ball and stick Information about Amoxapine [ edit ] Amoxapine is a tetracyclic antidepressant used for relief of symptoms of depression caused by either reactive or psychotic depression .
Liver safety of Amoxapine [ edit ] Amoxapine has been associated with a low rate of minor serum aminotransferase elevations during treatment and to very rare instances of clinically apparent acute liver injury.
Mechanism of action of Amoxapine [ edit ] Amoxapine (a mox' a peen) is a tetracyclic antidepressant belonging to the dibenzoxapine family, similar but somewhat distinct from classical tricyclic antidepressants. Amoxapine has been shown to be effective in both reactive and neurotic depression as well as in major, endogenous depressive disorders. As with other tricyclic antidepressants, the mechanism of action of amoxapine probably involves interruption of norepinephrine transmission. Amoxapine also blocks histaminic and cholinergic receptors which account for its mild sedative effects.
FDA approval information for Amoxapine [ edit ] Amoxapine was approved for use in the United States in 1992 and is available in tablets of 25, 50, 100 and 150 mg generically and previously under the brand name Ascendin .
Dosage and administration for Amoxapine [ edit ] Recommended doses are 50 mg two or three times daily initially, increasing based upon efficacy and tolerance and changing to once daily dosing, to as high as 300 mg once daily.
Side effects of Amoxapine [ edit ] Common side effects included drowsiness , dizziness , headache , blurred vision, dry mouth , and tremor . Less common and rare side effects include extrapyramidal signs and symptoms, tardive dyskinesia, suicidal ideation, heart arrhythmias and galactorrhea.
The following are antidepressant subclasses and drugs
MAO Inhibitors
Isocarboxazid , Phenelzine , Tranylcypromine
SNRIs
Duloxetine , Levomilnacipran , Venlafaxine
SSRIs
Citalopram , Escitalopram , Fluoxetine , Fluvoxamine , Paroxetine , Sertraline , Vilazodone , Vortioxetine
Tricyclics
Amitriptyline , Amoxapine , Clomipramine , Desipramine , Doxepin , Imipramine , Nortriptyline , Protriptyline , Trimipramine
Miscellaneous
Bupropion , Flibanserin , Mirtazapine , Nefazodone , Trazodone
The following are antidepressant subclasses and drugs
MAO Inhibitors
Isocarboxazid , Phenelzine , Tranylcypromine
SNRIs
Duloxetine , Levomilnacipran , Venlafaxine
SSRIs
Citalopram , Escitalopram , Fluoxetine , Fluvoxamine , Paroxetine , Sertraline , Vilazodone , Vortioxetine
Tricyclics
Amitriptyline , Amoxapine , Clomipramine , Desipramine , Doxepin , Imipramine , Nortriptyline , Protriptyline , Trimipramine
Miscellaneous
Bupropion , Flibanserin , Mirtazapine , Nefazodone , Trazodone
Pharmacodynamics
Adrenergic receptor modulators
α1
Agonists
Antagonists *
Abanoquil
Ajmalicine Alfuzosin Anisodamine Anisodine Atiprosin Atypical antipsychotics (e.g., brexpiprazole , clozapine , olanzapine , quetiapine , risperidone )Benoxathian Beta blockers (e.g., adimolol , amosulalol , arotinolol , carvedilol , eugenodilol , labetalol )Buflomedil Bunazosin Corynanthine Dapiprazole Domesticine Doxazosin Ergolines (e.g., acetergamine , ergotamine , dihydroergotamine , lisuride , nicergoline , terguride )Etoperidone Fenspiride Hydroxyzine Indoramin Ketanserin L-765,314 mCPP Mepiprazole Metazosin Monatepil Moxisylyte Naftopidil Nantenine Neldazosin Niaprazine Niguldipine Pardoprunox Pelanserin Perlapine Phendioxan Phenoxybenzamine Phentolamine Phenylpiperazine antidepressants (e.g., hydroxynefazodone , nefazodone , trazodone , triazoledione )Piperoxan Prazosin Quinazosin Quinidine Silodosin Spegatrine Spiperone Talipexole Tamsulosin Terazosin Tiodazosin Tolazoline Tetracyclic antidepressants (e.g., amoxapine , maprotiline , mianserin )Tricyclic antidepressants (e.g., amitriptyline , clomipramine , doxepin , imipramine , trimipramine )Trimazosin Typical antipsychotics (e.g., chlorpromazine , fluphenazine , loxapine , thioridazine )Urapidil WB-4101 Zolertine
α2
Agonists
Antagonists *
1-PP
Adimolol Amesergide Aptazapine Atipamezole Atypical antipsychotics (e.g., asenapine , brexpiprazole , clozapine , lurasidone , olanzapine , paliperidone , quetiapine , risperidone , zotepine )Azapirones (e.g., buspirone , gepirone , ipsapirone , tandospirone )BRL-44408 Buflomedil Cirazoline Efaroxan Esmirtazapine Fenmetozole Fluparoxan Idazoxan Ketanserin Lisuride mCPP Mianserin Mirtazapine NAN-190 Pardoprunox Phentolamine Phenoxybenzamine Piperoxan Piribedil Rauwolscine Rotigotine Setiptiline Spegatrine Spiroxatrine Sunepitron Terguride Tolazoline Typical antipsychotics (e.g., chlorpromazine , fluphenazine , loxapine , thioridazine )Yohimbine
β
Receptor (ligands )
GlyR
Positive modulators: Alcohols (e.g., brometone , chlorobutanol (chloretone) , ethanol (alcohol) , tert -butanol (2M2P)tribromoethanol , trichloroethanol , trifluoroethanol )Alkylbenzene sulfonate Anandamide Barbiturates (e.g., pentobarbital , sodium thiopental )Chlormethiazole D12-116 Dihydropyridines (e.g., nicardipine )Etomidate Ginseng constituents (e.g., ginsenosides (e.g., ginsenoside-Rf ))Glutamic acid (glutamate) Ivermectin Ketamine Neuroactive steroids (e.g., alfaxolone , pregnenolone (eltanolone) , pregnenolone acetate , minaxolone , ORG-20599 )Nitrous oxide Penicillin G Propofol Tamoxifen Tetrahydrocannabinol Triclofos Tropeines (e.g., atropine , bemesetron , cocaine , LY-278584 , tropisetron , zatosetron )Volatiles /gases (e.g., chloral hydrate , chloroform , desflurane , diethyl ether (ether) , enflurane , halothane , isoflurane , methoxyflurane , sevoflurane , toluene , trichloroethane (methyl chloroform) , trichloroethylene )Xenon Zinc Antagonists: 2-Aminostrychnine 2-Nitrostrychnine 4-Phenyl-4-formyl-N-methylpiperidine αEMBTL Bicuculline Brucine Cacotheline Caffeine Colchicine Colubrine Cyanotriphenylborate Dendrobine Diaboline Endocannabinoids (e.g., 2-AG , anandamide (AEA) )Gaboxadol (THIP) Gelsemine iso-THAZ Isobutyric acid Isonipecotic acid Isostrychnine Laudanosine N-Methylbicuculline N-Methylstrychnine N,N-Dimethylmuscimol Nipecotic acid Pitrazepin Pseudostrychnine Quinolines (e.g., 4-hydroxyquinoline , 4-hydroxyquinoline-3-carboxylic acid , 5,7-CIQA , 7-CIQ , 7-TFQ , 7-TFQA )RU-5135 Sinomenine Strychnine Thiocolchicoside Tutin Negative modulators: Amiloride Benzodiazepines (e.g., bromazepam , clonazepam , diazepam , flunitrazepam , flurazepam )Corymine Cyanotriphenylborate Daidzein Dihydropyridines (e.g., nicardipine , nifedipine , nitrendipine )Furosemide Genistein Ginkgo constituents (e.g., bilobalide , ginkgolides (e.g., ginkgolide A , ginkgolide B , ginkgolide C , ginkgolide J , ginkgolide M ))Imipramine NBQX Neuroactive steroids (e.g., 3α-androsterone sulfate , 3β-androsterone sulfate , deoxycorticosterone , DHEA sulfate , pregnenolone sulfate , progesterone )Opioids (e.g., codeine , dextromethorphan , dextrorphan , levomethadone , levorphanol , morphine , oripavine , pethidine , thebaine )Picrotoxin (i.e., picrotin and picrotoxinin )PMBA Riluzole Tropeines (e.g., bemesetron , LY-278584 , tropisetron , zatosetron )Verapamil Zinc NMDAR
Transporter (blockers )
Histamine receptor modulators
H1 *
Agonists: 2-Pyridylethylamine
Others: Atypical antipsychotics (e.g., aripiprazole , asenapine , brexpiprazole , brilaroxazine , clozapine , iloperidone , olanzapine , paliperidone , quetiapine , risperidone , ziprasidone , zotepine )Phenylpiperazine antidepressants (e.g., hydroxynefazodone , nefazodone , trazodone , triazoledione )Tetracyclic antidepressants (e.g., amoxapine , loxapine , maprotiline , mianserin , mirtazapine , oxaprotiline )Tricyclic antidepressants (e.g., amitriptyline , butriptyline , clomipramine , desipramine , dosulepin (dothiepin) , doxepin , imipramine , iprindole , lofepramine , nortriptyline , protriptyline , trimipramine )Typical antipsychotics (e.g., chlorpromazine , flupenthixol , fluphenazine , loxapine , perphenazine , prochlorperazine , thioridazine , thiothixene )
H2
H3
H4
Amoxapine chemical structure
Amoxapine ball-and-stick model
Amoxapine chemical structure
7-Hydroxyamoxapine chemical structure
8-Hydroxyamoxapine chemical structure
Amoxapine chemical structure
Amoxapine ball-and-stick model
7-Hydroxyamoxapine chemical structure
8-Hydroxyamoxapine chemical structure
