Duloxetine

Duloxetine chemical structure

Duloxetine hydrochloride 3D structure

Duloxetine (SNRI) packaging

Cymbalta 60mg capsule

Duloxetine is a type of antidepressant medication that is classified as a serotonin-norepinephrine reuptake inhibitor (SNRI). It is primarily used in the treatment of major depressive disorder (MDD), generalized anxiety disorder (GAD), fibromyalgia, and neuropathic pain.

Pharmacology

Duloxetine works by inhibiting the reuptake of serotonin and norepinephrine, two neurotransmitters in the brain. This results in an increase in the concentration of these neurotransmitters in the synaptic cleft, which leads to enhanced neurotransmission.

Medical uses

Duloxetine is approved for the treatment of major depressive disorder, generalized anxiety disorder, fibromyalgia, and neuropathic pain. It is also used off-label for the treatment of stress urinary incontinence.

Side effects

Common side effects of duloxetine include nausea, dry mouth, drowsiness, and sweating. More serious side effects can include suicidal thoughts, liver damage, and serotonin syndrome.

Contraindications

Duloxetine should not be used in individuals with a known hypersensitivity to the drug. It is also contraindicated in individuals with uncontrolled glaucoma due to the risk of increased intraocular pressure.

Interactions

Duloxetine can interact with a number of other medications, including other antidepressants, monoamine oxidase inhibitors (MAOIs), and certain antibiotics. It is important to discuss all medications and supplements with a healthcare provider before starting duloxetine.

See also

• Serotonin-norepinephrine reuptake inhibitors
• Antidepressant
• Major depressive disorder
• Generalized anxiety disorder
• Fibromyalgia
• Neuropathic pain

The following are antidepressant subclasses and drugs

MAO Inhibitors Isocarboxazid, Phenelzine, Tranylcypromine

SNRIs Duloxetine, Levomilnacipran, Venlafaxine

SSRIs Citalopram, Escitalopram, Fluoxetine, Fluvoxamine, Paroxetine, Sertraline, Vilazodone, Vortioxetine

Tricyclics Amitriptyline, Amoxapine, Clomipramine, Desipramine, Doxepin, Imipramine, Nortriptyline, Protriptyline, Trimipramine

Miscellaneous Bupropion, Flibanserin, Mirtazapine, Nefazodone, Trazodone

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