Metopon

Metopon is a potent opioid analgesic drug, approximately eight times more potent than morphine. It is used in medicine for the relief of severe pain, such as that experienced by cancer patients. Metopon is not commonly used, with other opioids such as morphine or fentanyl being preferred. It is still used in some cases, however, and is a valuable tool in the management of severe pain.

Pharmacology

Metopon acts by binding to the mu-opioid receptor, which is the same receptor that morphine and other opioids bind to. This binding causes a decrease in the perception of pain, as well as a decrease in the emotional response to pain. Metopon also has a high affinity for the delta-opioid receptor, which may contribute to its analgesic effects.

Side Effects

Like all opioids, Metopon has a number of side effects. These can include nausea, vomiting, constipation, and respiratory depression. In addition, Metopon can cause physical dependence and addiction, particularly if used over a long period of time or in high doses.

History

Metopon was first synthesized in the 1940s, and was used extensively in the 1950s and 1960s for the treatment of severe pain. However, its use has declined in recent years due to the development of other, more effective opioids.

See Also

• Opioid
• Morphine
• Fentanyl

References

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