Metopimazine

Metopimazine.svg

Metopimazine is a phenothiazine derivative with antiemetic properties. It is primarily used to prevent and treat nausea and vomiting. Metopimazine works by blocking dopamine receptors in the brain, which helps to reduce the sensation of nausea and the urge to vomit.

Pharmacology

Metopimazine is classified as a dopamine antagonist. It exerts its antiemetic effects by inhibiting the action of dopamine at the chemoreceptor trigger zone (CTZ) in the brain. This action helps to prevent the activation of the vomiting center in the medulla oblongata.

Indications

Metopimazine is indicated for the treatment of:

• Nausea
• Vomiting
• Motion sickness
• Postoperative nausea and vomiting

Dosage and Administration

Metopimazine is available in various forms, including oral tablets, oral solution, and suppositories. The dosage and administration depend on the severity of the symptoms and the patient's response to the medication. It is important to follow the prescribed dosage and not to exceed the recommended amount.

Side Effects

Common side effects of metopimazine may include:

• Drowsiness
• Dry mouth
• Constipation
• Blurred vision

Serious side effects, although rare, may include:

• Extrapyramidal symptoms
• Tardive dyskinesia
• Neuroleptic malignant syndrome

Contraindications

Metopimazine is contraindicated in patients with:

• Hypersensitivity to phenothiazines
• Severe liver disease
• Severe central nervous system depression

Precautions

Patients should use metopimazine with caution if they have:

• Cardiovascular disease
• Glaucoma
• Prostatic hypertrophy
• Parkinson's disease

Drug Interactions

Metopimazine may interact with other medications, including:

• Anticholinergic drugs
• CNS depressants
• Antihypertensive drugs

See Also

• Phenothiazine
• Dopamine antagonist
• Nausea
• Vomiting