5-HT2 receptor

5-HT2 Receptor

The 5-HT2 receptor (pronounced as "five H T two receptor") is a subtype of the 5-HT receptor that binds to the neurotransmitter serotonin. It is a G protein-coupled receptor (GPCR) and is known to play a significant role in the regulation of mood, anxiety, feeding, and reproductive behavior.

Etymology

The term "5-HT2 receptor" is derived from the chemical name for serotonin, 5-hydroxytryptamine, and the number 2 denotes the subtype of the receptor.

Subtypes

There are three known subtypes of the 5-HT2 receptor: 5-HT2A, 5-HT2B, and 5-HT2C. Each subtype has a different role in the body and is associated with different physiological and pathological conditions.

5-HT2A Receptor

The 5-HT2A receptor is primarily found in the central nervous system, specifically in areas of the brain associated with cognition, including the prefrontal cortex. It is thought to play a key role in the therapeutic effects and side effects of many types of drugs, including antipsychotics and hallucinogens.

5-HT2B Receptor

The 5-HT2B receptor is primarily found in the stomach fundus, liver, and heart. It is known to be involved in cardiac fibrosis and has been implicated in conditions such as pulmonary arterial hypertension and drug-induced valvulopathy.

5-HT2C Receptor

The 5-HT2C receptor is primarily found in the choroid plexus, but is also present in various other areas of the brain. It is involved in a variety of functions, including the regulation of mood, anxiety, feeding, and reproductive behavior.

Related Terms

External links

Medical encyclopedia article on 5-HT2 receptor
Wikipedia's article - 5-HT2 receptor

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