Dopexamine

Dopexamine is a synthetic analogue of dopamine that is administered intravenously in hospitals to reduce inflammation and to treat severe heart failure and acute kidney injury. Its primary use is in hospitals, where it is usually administered as a continuous intravenous infusion.

Pharmacology[edit]

Dopexamine stimulates beta-2 adrenergic receptors and, to a lesser extent, beta-1 adrenergic receptors, with the effect of reducing systemic vascular resistance. It also stimulates dopamine receptors in the kidneys, increasing urine output, which is beneficial in preventing renal failure. Dopexamine has no significant action on alpha adrenergic receptors, so it does not cause vasoconstriction.

Clinical Use[edit]

Dopexamine is used primarily in the treatment of heart failure and acute kidney injury. It is also used in the management of low cardiac output syndrome, particularly following cardiac surgery. Dopexamine has been shown to reduce the incidence of low cardiac output syndrome in patients undergoing coronary artery bypass surgery.

Side Effects[edit]

The most common side effects of dopexamine include tachycardia, hypotension, and arrhythmia. Less common side effects include nausea, vomiting, and diarrhea. Rare but serious side effects include myocardial ischemia and ventricular fibrillation.

Contraindications[edit]

Dopexamine is contraindicated in patients with pheochromocytoma, as it may provoke a hypertensive crisis. It is also contraindicated in patients with uncorrected tachyarrhythmia or ventricular fibrillation.

A[edit]

B[edit]

Brown atrophy of the heart

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A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z

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K[edit]

Keshan disease

L[edit]

Loeffler endocarditis

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Nonbacterial thrombotic endocarditis

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A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z

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Traumatic cardiac arrest

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Waon therapy

Health science - Medicine - Nephrology - edit
Diseases of the glomerulus
Lupus nephritis \| Post-infectious glomerulonephritis \| Minimal change disease \| Focal segmental glomerulosclerosis \| Diabetic nephropathy
Diseases of the proximal convoluted tubules
Fanconi syndrome (Type II renal tubular acidosis) \| renal cell carcinoma
Diseases of the distal convoluted tubules
pseudohypoaldosteronism (Type IV renal tubular acidosis)
Diseases of the collecting duct
Type I renal tubular acidosis
Tumours of the kidney
renal cell carcinoma \| Wilms' tumour (children)
Diseases of the renal vasculature
renal artery stenosis \| vasculitis \| atheroembolic disease
Tubulointerstitial diseases of the kidney
Drug-induced interstitial nephritis \| Obstructive nephropathy \| Radiation nephritis \| Reflux nephropathy \| Sarcoidosis
Genetic diseases of the kidney/syndromes associated with kidney dysfunction
Alport syndrome \| Polycystic kidney disease \| Wilms' tumour (children) von Hippel-Lindau syndrome \| Hereditary papillary renal carcinoma \| Birt-Hogg-Dube syndrome \| Hereditary renal carcinoma
Chronic kidney disease and related conditions
Chronic Kidney Disease Anemia in CKD \| Causes of CKD \| CKD Overview \| CKD Tests and Diagnosis \| Diabetic Kidney Disease \| Eating Right for CKD \| High Blood Pressure and Kidney Disease \| Managing CKD \| Mineral and Bone Disorder in CKD \| Nutrition for Advanced CKD in Adults \| Preventing CKD \| Quick Reference on UACR & GFR Kidney Failure Eating and Nutrition for Hemodialysis \| Financial Help for Treatment of Kidney Failure \| Hemodialysis \| Kidney Failure \| Kidney Transplant \| Peritoneal Dialysis Other Kidney Topics Acquired Cystic Kidney Disease \| Amyloidosis and Kidney Disease \| Diabetes Insipidus \| Ectopic Kidney \| Glomerular Diseases \| Goodpasture Syndrome \| Henoch-Schönlein Purpura \| IgA Nephropathy \| Kidney Dysplasia \| Kidney Infection (Pyelonephritis) \| Kidney Stones \| Lupus Nephritis \| Medullary Sponge Kidney \| Nephrotic Syndrome in Adults \| Pain Medicine and Kidney Damage \| Polycystic Kidney Disease (PKD) \| Renal Artery Stenosis \| Renal Tubular Acidosis \| Simple Kidney Cysts \| Solitary Kidney \| Your Kidneys and How They Work \| Your Urinary Tract and How It Works

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