Bupranolol
Overview of the non-selective beta blocker Bupranolol
Bupranolol
Bupranolol is a non-selective beta blocker used in the management of hypertension and other cardiovascular conditions. It is known for its ability to block both beta-1 and beta-2 adrenergic receptors, which are involved in the regulation of heart rate and vascular tone.
Pharmacology
Bupranolol works by inhibiting the action of epinephrine and norepinephrine on beta receptors, leading to a decrease in heart rate, cardiac output, and blood pressure. This makes it effective in treating conditions such as angina pectoris, arrhythmia, and myocardial infarction.
Mechanism of Action
Bupranolol binds to beta-adrenergic receptors, preventing the binding of endogenous catecholamines. This blockade results in decreased sympathetic nervous system activity, which reduces myocardial oxygen demand and improves cardiac efficiency.
Clinical Uses
Bupranolol is primarily used in the treatment of:
Side Effects
Common side effects of bupranolol include:
Contraindications
Bupranolol should not be used in patients with:
- Asthma
- Chronic obstructive pulmonary disease (COPD)
- Severe bradycardia
- Heart block
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Contributors: Prab R. Tumpati, MD
