Terfenadine

From WikiMD.org
Jump to navigation Jump to search

Terfenadine

Terfenadine (pronounced: ter-FEN-a-deen) is a non-sedating antihistamine that was previously marketed under the trade name Seldane. It was discovered by Merck Sharp & Dohme in 1973 and was the first non-sedating antihistamine to be marketed.

Etymology

The name "Terfenadine" is derived from its chemical name, which is (RS)-1-(4-tert-Butylphenyl)-4-{4-[hydroxy(diphenyl)methyl]piperidin-1-yl}butan-1-ol.

Pharmacology

Terfenadine acts as a peripheral H1 receptor antagonist, which means it inhibits the action of histamine at the H1 receptor sites. This reduces the negative symptoms associated with histamine H1 receptor stimulation, such as sneezing, itching, and rhinorrhea.

Side Effects

The most common side effects of terfenadine include drowsiness, headache, and gastrointestinal disturbances. In rare cases, it can cause serious cardiac arrhythmias, particularly in patients with pre-existing heart conditions or who are taking other medications.

Related Terms

External links

Esculaap.svg

This WikiMD dictionary article is a stub. You can help make it a full article.


Languages: - East Asian 中文, 日本, 한국어, South Asian हिन्दी, Urdu, বাংলা, తెలుగు, தமிழ், ಕನ್ನಡ,
Southeast Asian Indonesian, Vietnamese, Thai, မြန်မာဘာသာ, European español, Deutsch, français, русский, português do Brasil, Italian, polski