Terfenadine
Terfenadine
Terfenadine (pronounced: ter-FEN-a-deen) is a non-sedating antihistamine that was previously marketed under the trade name Seldane. It was discovered by Merck Sharp & Dohme in 1973 and was the first non-sedating antihistamine to be marketed.
Etymology
The name "Terfenadine" is derived from its chemical name, which is (RS)-1-(4-tert-Butylphenyl)-4-{4-[hydroxy(diphenyl)methyl]piperidin-1-yl}butan-1-ol.
Pharmacology
Terfenadine acts as a peripheral H1 receptor antagonist, which means it inhibits the action of histamine at the H1 receptor sites. This reduces the negative symptoms associated with histamine H1 receptor stimulation, such as sneezing, itching, and rhinorrhea.
Side Effects
The most common side effects of terfenadine include drowsiness, headache, and gastrointestinal disturbances. In rare cases, it can cause serious cardiac arrhythmias, particularly in patients with pre-existing heart conditions or who are taking other medications.
Related Terms
External links
- Medical encyclopedia article on Terfenadine
- Wikipedia's article - Terfenadine
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