Κ-opioid receptor
Κ-opioid receptor (KOR) is a type of opioid receptor that binds to various opioids. It is one of the four types of opioid receptors found in the human body, the others being the mu-opioid receptor (MOR), delta-opioid receptor (DOR), and nociceptin receptor (NOP). The KOR is encoded by the OPRK1 gene in humans.
Function
The KOR is involved in a variety of physiological processes, including pain perception, consciousness, motor control, and mood regulation. It is also implicated in the reward system, and its activation can lead to dysphoria and hallucinations.
Ligands
Various ligands can bind to the KOR, including both agonists and antagonists. Agonists include dynorphin, a naturally occurring opioid peptide, and synthetic opioids such as U-50488 and Salvinorin A. Antagonists include norbinaltorphimine and JDTic.
Clinical significance
The KOR has been a target for drug development, with potential applications in the treatment of pain, addiction, and mood disorders. However, the development of KOR agonists has been limited by their dysphoric and hallucinogenic side effects.
See also
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