Alprenolol

Alprenolol

Alprenolol is a non-selective beta blocker and a non-cardioselective beta-adrenergic antagonist. It was first synthesized in 1967 by the Swedish pharmaceutical company Astra AB, now known as AstraZeneca. Alprenolol is used in the treatment of various cardiovascular disorders, such as hypertension, angina pectoris, and arrhythmia.

Pharmacology

Alprenolol works by blocking the action of epinephrine and norepinephrine, two hormones that stimulate the heart and blood vessels. By blocking these hormones, Alprenolol reduces heart rate, blood pressure, and strain on the heart.

Clinical Use

Alprenolol is primarily used to treat hypertension and angina pectoris. It is also used to prevent and treat heart arrhythmias and is sometimes used in the treatment of anxiety and migraine.

Side Effects

Common side effects of Alprenolol include fatigue, cold hands and feet, slow heartbeat, and sleep disturbances. Less common side effects include depression, shortness of breath, and weight gain.

Contraindications

Alprenolol is contraindicated in patients with asthma, bradycardia, and certain types of heart block. It should be used with caution in patients with diabetes or peripheral vascular disease.

See Also

• Beta Blockers
• Hypertension
• Angina Pectoris
• Arrhythmia

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