Adrafinil
Adrafinil
Adrafinil (/ædrəˈfɪnɪl/; brand name Olmifon) is a eugeroic that was formerly used in France to promote alertness, attention, wakefulness, mood, and other parameters, particularly in the elderly. It was also used off-label by individuals who wished to avoid fatigue, such as night workers or others who needed to stay awake and alert for long periods of time.
Etymology
The term "Adrafinil" is derived from the French words "adra-", meaning "alertness", and "-finil", which is a common ending for pharmaceuticals that affect the central nervous system.
Pharmacology
Adrafinil is a prodrug; it is primarily metabolized in vivo to modafinil, resulting in nearly identical pharmacological effects. Unlike modafinil, however, it takes time for the metabolite to accumulate to active levels in the bloodstream. Effects usually are apparent within 45–60 minutes when taken orally on an empty stomach.
Side Effects
Side effects are rare with adrafinil and are generally mild. They can include insomnia, headache, stomach pain, nausea, heart palpitations, and dizziness. In some cases, these side effects can be severe enough to warrant discontinuation of treatment.
Legal Status
Adrafinil is unregulated in the United States, Canada, and the United Kingdom. In some countries, such as Australia, it is classified as a Schedule 4 (prescription only) drug.
See Also
References
External links
- Medical encyclopedia article on Adrafinil
- Wikipedia's article - Adrafinil
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