Arotinolol

Arotinolol

Chemical structure of Arotinolol

Arotinolol is a non-selective beta blocker with additional alpha-1 adrenergic receptor blocking properties. It is primarily used in the management of hypertension and certain types of cardiac arrhythmias.

Pharmacology

Arotinolol acts by blocking both beta-adrenergic receptors and alpha-1 adrenergic receptors. This dual action results in a decrease in heart rate, cardiac output, and blood pressure. The blockade of alpha-1 receptors leads to vasodilation, which further contributes to its antihypertensive effects.

Mechanism of Action

Arotinolol binds to beta-1 and beta-2 adrenergic receptors, inhibiting the effects of catecholamines such as epinephrine and norepinephrine. This results in a reduction of sympathetic nervous system activity, leading to decreased myocardial contractility and heart rate. The alpha-1 blockade causes relaxation of vascular smooth muscle, reducing peripheral vascular resistance.

Clinical Uses

Arotinolol is used in the treatment of:

• Hypertension
• Angina pectoris
• Certain types of arrhythmias

It may also be used off-label for other cardiovascular conditions where beta blockade is beneficial.

Side Effects

Common side effects of arotinolol include:

• Bradycardia
• Hypotension
• Dizziness
• Fatigue

Less common but serious side effects can include:

• Bronchospasm
• Heart failure
• Peripheral edema

Contraindications

Arotinolol should not be used in patients with:

• Asthma or chronic obstructive pulmonary disease (COPD)
• Severe bradycardia
• Cardiogenic shock
• Second or third-degree heart block without a pacemaker

Related pages

• Beta blocker
• Adrenergic receptor
• Hypertension
• Cardiac arrhythmia