Metipranolol

Metipranolol is a non-selective beta-adrenergic blocking agent used in the treatment of glaucoma and ocular hypertension. It is a white, odorless, crystalline powder that is soluble in water, ethanol, and chloroform.

Pharmacology

Metipranolol works by reducing the production of aqueous humour in the eye, thereby decreasing intraocular pressure. It does this by blocking beta-adrenergic receptors in the ciliary body, which is responsible for the production of aqueous humour.

Indications

Metipranolol is indicated for the reduction of elevated intraocular pressure in patients with ocular hypertension or open-angle glaucoma. It is often used when other treatments have failed or are not suitable.

Side Effects

Common side effects of Metipranolol include eye irritation, eye pain, and blurred vision. Systemic side effects can occur, including slow heart rate, low blood pressure, and bronchospasm.

Contraindications

Metipranolol is contraindicated in patients with known hypersensitivity to the drug or any of its components. It is also contraindicated in patients with sinus bradycardia, heart block greater than first degree, cardiogenic shock, and overt cardiac failure.

Interactions

Metipranolol can interact with other medications, including other beta blockers, calcium channel blockers, and digoxin. These interactions can lead to changes in blood pressure, heart rate, and other cardiovascular parameters.

See Also

• Beta blocker
• Glaucoma
• Ocular hypertension

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  Metipranolol