Nicergoline

Nicergoline (sold under the brand name Sermion among others) is an ergot derivative used to treat senile dementia and other disorders with vascular origins. It has been used internationally for frontotemporal dementia, as well as early onset in Lewy body dementia and Parkinson's disease dementia.

structure

Mechanism of action

Nicergoline decreases vascular resistance and increases arterial blood flow in the brain, improving the utilization of oxygen and glucose by brain cells. It has similar vasoactive properties in other areas of the body, particularly the lungs.

Safety profile

Unlike many other ergolines, such as ergotamine, nicergoline is not associated with cardiac fibrosis.

Indications and usage

Nicergoline is primarily used for the treatment of:

• Senile dementia
• Vascular disorders, including ischemic stroke
• Frontotemporal dementia
• Early onset in Lewy body dementia
• Parkinson's disease dementia

Contraindications

Nicergoline is contraindicated in patients with a known hypersensitivity to the drug or other ergot derivatives.

Side effects

Side effects of nicergoline may include:

• Dizziness
• Nausea
• Headache
• Hypotension
• Gastrointestinal discomfort

See also

• Ergotamine
• Ergot alkaloids
• Senile dementia
• Frontotemporal dementia
• Lewy body dementia

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