Azapirone

Azapirone is a class of drugs used in the treatment of anxiety disorders and depression. They are commonly known as anxiolytics and have a different mechanism of action compared to other anti-anxiety medications such as benzodiazepines.

Mechanism of Action

Azapirones work by modulating the serotonin system in the brain. They are partial agonists at the 5-HT1A receptor, which means they stimulate the receptor to a lesser extent than a full agonist. This results in a balance between stimulation and inhibition of the serotonin system, which can help to reduce symptoms of anxiety and depression.

Uses

Azapirones are primarily used to treat generalized anxiety disorder and panic disorder. They may also be used off-label for other conditions such as social anxiety disorder and post-traumatic stress disorder.

Side Effects

Common side effects of azapirones include dizziness, headaches, and nausea. In rare cases, they can cause serotonin syndrome, a potentially life-threatening condition characterized by agitation, hallucinations, rapid heartbeat, and high body temperature.

Examples

Some examples of azapirones include buspirone, gepirone, and ipsapirone. Buspirone is the most commonly prescribed azapirone and is available under the brand name Buspar.

See Also

• Anxiety Disorders
• Depression
• Serotonin
• 5-HT1A receptor
• Benzodiazepines

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Azapirone

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