Ecastolol

A comprehensive overview of the beta-blocker Ecastolol

Ecastolol

Chemical structure of Ecastolol

Ecastolol is a beta-blocker medication primarily used in the management of hypertension and certain types of cardiac arrhythmias. It functions by blocking the effects of epinephrine (adrenaline) on the beta-adrenergic receptors in the heart, which results in a decrease in heart rate and blood pressure.

Pharmacology

Ecastolol is a selective beta-1 adrenergic receptor antagonist. This selectivity means it primarily affects the heart and has less impact on beta-2 receptors found in the lungs and vascular smooth muscle. This property makes it a preferred choice in patients with asthma or chronic obstructive pulmonary disease (COPD), as it is less likely to cause bronchoconstriction.

Mechanism of Action

Ecastolol works by inhibiting the action of catecholamines, such as epinephrine and norepinephrine, on beta-1 adrenergic receptors. This leads to a reduction in myocardial contractility and heart rate, thereby decreasing cardiac output and lowering blood pressure. Additionally, it reduces the release of renin from the kidneys, contributing to its antihypertensive effects.

Clinical Uses

Ecastolol is indicated for the treatment of:

• Hypertension
• Angina pectoris
• Heart failure
• Myocardial infarction
• Certain types of arrhythmias, such as atrial fibrillation

Side Effects

Common side effects of Ecastolol include:

• Bradycardia
• Fatigue
• Dizziness
• Cold extremities
• Gastrointestinal disturbances

Serious side effects may include:

• Heart block
• Heart failure
• Bronchospasm in susceptible individuals

Contraindications

Ecastolol should not be used in patients with:

• Severe bradycardia
• Second or third-degree heart block
• Cardiogenic shock
• Decompensated heart failure

Administration

Ecastolol is typically administered orally, with dosage adjusted based on the patient's response and clinical condition. It is important to monitor blood pressure and heart rate regularly during treatment.

Related pages

• Beta-blocker
• Hypertension
• Cardiac arrhythmia
• Myocardial infarction