Tampramine

Tampramine' (developmental code name AHR-9,377) is a tricyclic antidepressant (TCA) synthesized in the 1980s. Unlike typical TCAs, Tampramine is characterized by its selective inhibition of the norepinephrine reuptake mechanism, distinguishing it from other members of its class which commonly exhibit significant affinity towards adrenergic, histaminergic, and muscarinic receptors. This selectivity renders Tampramine an interesting compound within the domain of antidepressant drugs, although it was never introduced to the market.

Pronunciation

Tam-pra-mine

Mechanism of Action

Tampramine functions primarily as a selective norepinephrine reuptake inhibitor (NRI), a mechanism that increases the concentration of norepinephrine in the synaptic cleft by preventing its reabsorption into the presynaptic neuron. This action is believed to contribute to its antidepressant effects. The negligible affinity Tampramine shows for adrenergic, histaminergic, and muscarinic receptors minimizes the risk of side effects commonly associated with traditional TCAs, such as orthostatic hypotension, sedation, and anticholinergic effects.

Preclinical Studies

In animal models, particularly the forced swim test (FST) which is commonly used to evaluate antidepressant efficacy, Tampramine demonstrated significant potential in reducing signs of depression. Despite these promising results in preclinical trials, it is not known to have undergone clinical trials in humans to assess its safety and efficacy.

Development and Market Status

Tampramine's development was ultimately halted, and the drug was not marketed. The reasons behind this decision could include various factors such as commercial considerations, potential competition from other antidepressants with more established profiles, or strategic priorities of the developing company. The cessation of its development leaves Tampramine as an example of the challenges faced in bringing new psychiatric medications from the laboratory to the clinic.

Related Terms

• Tricyclic Antidepressant
• Selective Norepinephrine Reuptake Inhibitor
• Antidepressant
• Forced Swim Test
• Psychopharmacology

See Also

• Drug Development Process
• Norepinephrine in Depression
• Preclinical Drug Development
• History of Antidepressants

External links

• Medical encyclopedia article on Tampramine
• Wikipedia's article - Tampramine

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