5-HT2B receptor

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5-HT2B Receptor

The 5-HT2B receptor (pronounced as "five H T two B receptor"), also known as the serotonin 2B receptor, is a protein that in humans is encoded by the HTR2B gene. It is a subtype of the 5-HT2 receptor that binds the neurotransmitter serotonin, also known as 5-hydroxytryptamine (5-HT).

Etymology

The term "5-HT2B receptor" is derived from the chemical name of serotonin, 5-hydroxytryptamine, and the classification of this receptor as a subtype of the 5-HT2 receptor family. The "B" in 5-HT2B denotes its distinct characteristics from other subtypes within the same family.

Function

The 5-HT2B receptor is a member of the 5-HT2 receptor family that is located primarily in the stomach, liver, and kidney. It plays a crucial role in the regulation of heart valve function and has been implicated in conditions such as pulmonary arterial hypertension and drug-induced valvulopathy.

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