Clorotepine
Clorotepine is a typical antipsychotic medication belonging to the class of thioxanthene derivatives. It is primarily used in the treatment of schizophrenia and other psychotic disorders. Clorotepine is known for its dopamine receptor antagonistic properties, which help in alleviating symptoms of psychosis.
Pharmacology
Clorotepine works by blocking dopamine receptors in the brain, particularly the D2 receptors. This action helps to reduce the effects of excess dopamine, which is believed to contribute to the symptoms of schizophrenia and other psychotic disorders. The medication also has some affinity for serotonin receptors, which may contribute to its therapeutic effects.
Indications
Clorotepine is indicated for the treatment of:
- Schizophrenia
- Bipolar disorder (manic episodes)
- Severe anxiety and agitation in psychotic patients
Side Effects
Common side effects of clorotepine include:
- Sedation
- Weight gain
- Extrapyramidal symptoms such as tremors, rigidity, and bradykinesia
- Anticholinergic effects like dry mouth, constipation, and blurred vision
Serious side effects may include:
Contraindications
Clorotepine is contraindicated in patients with:
- Known hypersensitivity to clorotepine or other thioxanthenes
- Severe cardiovascular disease
- Liver disease
- Kidney disease
Dosage
The dosage of clorotepine varies depending on the condition being treated and the patient's response to the medication. It is typically administered orally, and the dosage is gradually adjusted to achieve the desired therapeutic effect while minimizing side effects.
History
Clorotepine was developed in the mid-20th century as part of the search for effective antipsychotic medications. It was one of the early thioxanthene derivatives to be used clinically and has since been replaced by newer antipsychotic drugs with more favorable side effect profiles.
See Also
References
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