Hydroxynefazodone
| Hydroxynefazodone | |
|---|---|
| |
| INN | |
| Drug class | |
| Routes of administration | |
| Pregnancy category | |
| Bioavailability | |
| Metabolism | |
| Elimination half-life | |
| Excretion | |
| Legal status | |
| CAS Number | |
| PubChem | |
| DrugBank | |
| ChemSpider | |
| KEGG | |
Hydroxynefazodone is a metabolite of the antidepressant drug nefazodone. It is formed in the body through the hydroxylation of nefazodone, primarily in the liver. Hydroxynefazodone is one of several active metabolites of nefazodone, contributing to its pharmacological effects.
Pharmacology[edit]
Hydroxynefazodone, like its parent compound nefazodone, acts as a serotonin antagonist and reuptake inhibitor (SARI). It inhibits the reuptake of serotonin and norepinephrine, and also acts as an antagonist at the 5-HT2A receptor. This dual action is thought to contribute to its antidepressant effects.
Metabolism[edit]
Nefazodone is metabolized in the liver by the cytochrome P450 enzyme system, particularly by CYP3A4. Hydroxynefazodone is one of the primary metabolites formed during this process. The formation of hydroxynefazodone involves the addition of a hydroxyl group to the nefazodone molecule, which increases its water solubility and facilitates its excretion from the body.
Clinical Significance[edit]
The presence of hydroxynefazodone in the body is significant because it contributes to the overall therapeutic effects of nefazodone. However, nefazodone has been associated with hepatotoxicity, which has led to its withdrawal from the market in some countries. The role of hydroxynefazodone in this adverse effect is not fully understood, but it is considered less hepatotoxic than nefazodone itself.
Chemical Structure[edit]
Hydroxynefazodone has a complex chemical structure characterized by a triazolone ring, a piperazine moiety, and a chlorophenyl group. The hydroxylation of nefazodone to form hydroxynefazodone occurs at the triazolone ring, which is a key feature of its chemical structure.
Related Compounds[edit]
Hydroxynefazodone is one of several metabolites of nefazodone. Other metabolites include mCPP (meta-chlorophenylpiperazine) and dihydroxynornefazodone. These metabolites vary in their pharmacological activity and contribute differently to the effects and side effects of nefazodone.
Related Pages[edit]
Ad. Transform your health with W8MD Weight Loss, Sleep & MedSpa
Tired of being overweight?
Special offer:
Budget GLP-1 weight loss medications
- Semaglutide starting from $29.99/week and up with insurance for visit of $59.99 and up per week self pay.
- Tirzepatide starting from $45.00/week and up (dose dependent) or $69.99/week and up self pay
✔ Same-week appointments, evenings & weekends
Learn more:
- GLP-1 weight loss clinic NYC
- W8MD's NYC medical weight loss
- W8MD Philadelphia GLP-1 shots
- Philadelphia GLP-1 injections
- Affordable GLP-1 shots NYC
- Budget GLP-1 shots
|
WikiMD Medical Encyclopedia |
Medical Disclaimer: WikiMD is for informational purposes only and is not a substitute for professional medical advice. Content may be inaccurate or outdated and should not be used for diagnosis or treatment. Always consult your healthcare provider for medical decisions. Verify information with trusted sources such as CDC.gov and NIH.gov. By using this site, you agree that WikiMD is not liable for any outcomes related to its content. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates, categories Wikipedia, licensed under CC BY SA or similar.
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
