Penfluridol

An antipsychotic medication

Penfluridol
INN
Drug class
Routes of administration
Pregnancy category
Bioavailability
Metabolism
Elimination half-life
Excretion
Legal status
CAS Number
PubChem
DrugBank
ChemSpider
KEGG

Penfluridol is a long-acting antipsychotic medication primarily used in the treatment of schizophrenia and other chronic psychotic disorders. It belongs to the class of diphenylbutylpiperidine derivatives and is known for its prolonged duration of action, allowing for once-weekly dosing.

Pharmacology

Penfluridol acts as a dopamine receptor antagonist, particularly targeting the D2 receptors in the brain. This action helps to alleviate symptoms of psychosis, such as hallucinations and delusions. The drug's long half-life contributes to its extended duration of effect, making it suitable for patients who may have difficulty adhering to daily medication regimens.

Clinical Use

Penfluridol is indicated for the management of chronic psychotic disorders, including schizophrenia. Its once-weekly administration is advantageous in improving medication adherence in patients who struggle with daily dosing schedules. The medication is typically administered orally.

Side Effects

Common side effects of penfluridol include extrapyramidal symptoms, such as tremors, rigidity, and bradykinesia. Other potential side effects include sedation, weight gain, and anticholinergic effects like dry mouth and constipation. Long-term use may lead to tardive dyskinesia, a condition characterized by involuntary, repetitive body movements.

History

Penfluridol was developed in the 1960s and introduced into clinical practice in the 1970s. It was one of the first long-acting oral antipsychotics, providing an alternative to injectable depot antipsychotics. Despite its benefits, the use of penfluridol has declined with the advent of newer atypical antipsychotics that offer improved side effect profiles.

Related pages

• Antipsychotic
• Schizophrenia
• Dopamine receptor antagonist
• Extrapyramidal symptoms

• 

  Penfluridol