Reuptake inhibitor

Reuptake inhibitor is a type of drug that acts on the neurotransmitter system in the brain. These drugs are often used in the treatment of various mental disorders, including depression, anxiety disorders, and obsessive-compulsive disorder (OCD).

Mechanism of Action

Reuptake inhibitors work by blocking the reuptake of certain neurotransmitters in the brain. This increases the amount of these neurotransmitters available in the synaptic cleft, which can help to improve mood and reduce symptoms of mental disorders.

There are several types of reuptake inhibitors, including:

• Selective serotonin reuptake inhibitors (SSRIs)
• Serotonin-norepinephrine reuptake inhibitors (SNRIs)
• Norepinephrine-dopamine reuptake inhibitors (NDRIs)
• Tricyclic antidepressants (TCAs)

Each of these types of reuptake inhibitors works on different neurotransmitters.

Uses

Reuptake inhibitors are commonly used in the treatment of a variety of mental disorders. They are most commonly used to treat depression, but can also be used for other conditions, such as anxiety disorders, OCD, post-traumatic stress disorder (PTSD), and certain types of chronic pain.

Side Effects

Like all drugs, reuptake inhibitors can have side effects. These can include nausea, insomnia, weight gain, and sexual dysfunction. In rare cases, they can also cause more serious side effects, such as serotonin syndrome.

See Also

• Antidepressant
• Neurotransmitter
• Synaptic cleft

References

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