Tropisetron

Medication used to treat nausea and vomiting

Tropisetron
INN
Drug class
Routes of administration	Oral, Intravenous
Pregnancy category
Bioavailability
Metabolism
Elimination half-life
Excretion
Legal status
CAS Number	89565-68-4
PubChem	5583
DrugBank	DB00757
ChemSpider	5383
KEGG	D00372

Tropisetron is a pharmaceutical drug used primarily as an antiemetic to treat nausea and vomiting caused by chemotherapy and radiotherapy. It is also used to prevent postoperative nausea and vomiting. Tropisetron is a selective 5-HT3 receptor antagonist, which means it works by blocking the action of serotonin at the 5-HT3 receptors.

Medical uses

Tropisetron is indicated for the prevention and treatment of nausea and vomiting induced by chemotherapy and radiotherapy. It is also used to prevent postoperative nausea and vomiting. The drug is administered either orally or intravenously.

Mechanism of action

Tropisetron works by selectively blocking the 5-HT3 receptors in the central nervous system and the gastrointestinal tract. By inhibiting the action of serotonin at these receptors, it prevents the activation of the vomiting reflex.

Pharmacokinetics

Tropisetron is well absorbed after oral administration. It undergoes hepatic metabolism and is excreted primarily via the kidneys. The elimination half-life of tropisetron is approximately 8 hours.

Side effects

Common side effects of tropisetron include headache, constipation, and dizziness. Rare but serious side effects may include allergic reactions and cardiac arrhythmias.

Contraindications

Tropisetron is contraindicated in patients with known hypersensitivity to the drug or any of its components. Caution is advised in patients with hepatic impairment or renal impairment.

See also

• Ondansetron
• Granisetron
• Palonosetron
• Chemotherapy-induced nausea and vomiting
• Postoperative nausea and vomiting

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  Tropisetron 2D Structure

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  Tropisetron 3D Animation