Amthamine
Amthamine is a potent and selective agonist for the H2 subtype of histamine receptors. This selectivity has made Amthamine a valuable research tool for studying both the physiological and pathological roles of H2 receptors, particularly in the context of gastric secretion.
Background
Histamine is a biogenic amine that plays a pivotal role in various physiological processes, ranging from inflammatory responses to gastric acid secretion. Its actions are mediated by four known receptors: H1, H2, H3, and H4. Among these, the H2 receptor is especially prominent in the gastric parietal cells where it regulates acid secretion.
Pharmacology
Mechanism of Action
Amthamine, acting as a selective agonist, binds to the H2 receptors, leading to an increase in cyclic AMP levels within the cell. This elevated cAMP subsequently activates protein kinase A, which in turn stimulates proton pumps, resulting in increased acid secretion in the stomach.
Uses in Research
- Gastric Secretion Studies: Given its effect on stomach acid production, Amthamine has been employed in in vitro and in vivo experiments to understand the regulation of gastric acid secretion and the potential implications of hyper or hypoacidity.
- Exploring Other H2 Functions: Beyond the stomach, H2 receptors are distributed in various tissues, including the heart, uterus, and vascular smooth muscle. Amthamine's selectivity for H2 has helped in probing these lesser-known actions of histamine.
Adverse Effects
As a research tool, Amthamine is typically not used therapeutically in humans. However, over-activation of the H2 receptor can theoretically lead to excessive gastric acid production, potentially exacerbating conditions like peptic ulcer disease or GERD.
Comparative Agents
- Histamine: The endogenous ligand for all histamine receptors.
- Tiotidine and Ranitidine: H2 receptor antagonists commonly used in the clinical setting to decrease acid secretion.
See Also
Transform your life with W8MD's budget GLP-1 injections from $125.
W8MD offers a medical weight loss program to lose weight in Philadelphia. Our physician-supervised medical weight loss provides:
- Most insurances accepted or discounted self-pay rates. We will obtain insurance prior authorizations if needed.
- Generic GLP1 weight loss injections from $125 for the starting dose.
- Also offer prescription weight loss medications including Phentermine, Qsymia, Diethylpropion, Contrave etc.
NYC weight loss doctor appointments
Start your NYC weight loss journey today at our NYC medical weight loss and Philadelphia medical weight loss clinics.
- Call 718-946-5500 to lose weight in NYC or for medical weight loss in Philadelphia 215-676-2334.
- Tags:NYC medical weight loss, Philadelphia lose weight Zepbound NYC, Budget GLP1 weight loss injections, Wegovy Philadelphia, Wegovy NYC, Philadelphia medical weight loss, Brookly weight loss and Wegovy NYC
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates, categories Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
