Guanabenz

From WikiMD's medical encyclopedia

Guanabenz is an alpha-2 adrenergic agonist that is commonly used as an antihypertensive agent. It works by reducing the amount of norepinephrine available to bind to alpha-2 receptors in the brain, which in turn reduces the activity of the sympathetic nervous system and lowers blood pressure.

Mechanism of Action

Guanabenz works by stimulating alpha-2 adrenergic receptors in the brain. This reduces the release of norepinephrine, a neurotransmitter that increases heart rate and blood pressure. By reducing the amount of norepinephrine, Guanabenz effectively lowers blood pressure.

Uses

Guanabenz is primarily used to treat hypertension, or high blood pressure. It may be used alone or in combination with other antihypertensive agents.

Side Effects

Common side effects of Guanabenz include drowsiness, dry mouth, and fatigue. Less common side effects can include depression, constipation, and impotence.

Contraindications

Guanabenz should not be used in patients with a known hypersensitivity to the drug. It should also be used with caution in patients with severe coronary insufficiency, recent myocardial infarction, or cerebrovascular disease.

Drug Interactions

Guanabenz may interact with other medications, including other antihypertensive agents, antidepressants, and sedatives. It is important to inform your healthcare provider of all medications you are currently taking.

See Also

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Guanabenz

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