Eticlopride

Eticlopride is a selective Dopamine antagonist that is used in scientific research. It has a high affinity for the Dopamine D2 receptor, and has no appreciable affinity for the Dopamine D1 receptor. Eticlopride is not approved for use in humans, but is commonly used in animal models to study the role of the D2 receptor in behavior.

Pharmacology

Eticlopride acts by blocking the action of dopamine, a neurotransmitter in the brain that is involved in mood, motivation, and reward. It does this by binding to the dopamine D2 receptor, preventing dopamine from activating it. This can alter the behavior of animals in ways that are useful for studying the role of dopamine in the brain.

Uses in Research

Eticlopride is used in a variety of research contexts. For example, it is often used in studies of drug addiction, as it can reduce the rewarding effects of drugs like cocaine and amphetamine. It is also used in studies of Parkinson's disease, as it can mimic some of the symptoms of this condition by reducing dopamine activity.

Side Effects

As eticlopride is not approved for use in humans, its side effects are not well-studied. However, in animal models, it can cause side effects similar to those of other dopamine antagonists, such as tardive dyskinesia, a movement disorder.

See Also

• Dopamine antagonist
• Dopamine D2 receptor
• Dopamine D1 receptor

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