Leu-enkephalin
Leu-enkephalin is a naturally occurring opioid peptide that is found in the brain and spinal cord. It is one of the two forms of enkephalin, the other being Met-enkephalin. Leu-enkephalin is a pentapeptide, meaning it is composed of five amino acids. It has the amino acid sequence Tyr-Gly-Gly-Phe-Leu.
Structure and Function
Leu-enkephalin is derived from the proenkephalin gene and is released by neurons as a neurotransmitter or neuromodulator. It binds to opioid receptors in the brain and spinal cord, where it inhibits the release of GABA. This results in an increase in dopamine release, which contributes to the analgesic effects of Leu-enkephalin.
Clinical Significance
Leu-enkephalin has been studied for its potential role in various medical conditions, including pain management, depression, and Parkinson's disease. It is thought to play a role in the body's natural pain relief system, and drugs that mimic its effects are used in the treatment of chronic pain.
See Also
References
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Contributors: Prab R. Tumpati, MD
