Tolazoline

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Tolazoline

Tolazoline (pronounced toh-luh-ZOH-leen) is a non-selective competitive antagonist of the alpha-adrenergic receptor. It is primarily used in the treatment of persistent pulmonary hypertension of the newborn (PPHN).

Etymology

The term "Tolazoline" is derived from the chemical structure of the drug, which is a tolyl-substituted imidazoline.

Usage

Tolazoline is used in the treatment of persistent pulmonary hypertension of the newborn (PPHN). It works by relaxing the smooth muscles in the walls of the blood vessels, particularly in the lungs, thereby reducing pulmonary arterial pressure and improving oxygenation.

Related Terms

  • Alpha-adrenergic receptor: A type of protein on the surface of cells that interacts with certain chemicals in the body to cause various physiological effects.
  • Antagonist: A substance that interferes with or inhibits the physiological action of another.
  • Pulmonary hypertension: A condition characterized by high blood pressure in the arteries to the lungs.
  • Newborn: An infant in the first few hours or days after birth.

Side Effects

Like all medications, Tolazoline can cause side effects. These may include hypotension, bradycardia, and arrhythmias. It is important to monitor patients closely while they are receiving this medication.

See Also

External links

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