Aptazapine
Aptazapine
Aptazapine (pronounced: ap-ta-za-peen) is a tricyclic antidepressant (TCA) that was developed in the late 1970s but was never marketed. It is structurally related to mianserin and mirtazapine.
Etymology
The term "Aptazapine" is derived from the chemical structure of the drug. The prefix "Apta-" is derived from the Latin word "aptus" meaning "fit" or "appropriate", and "-zapine" is a common suffix used in the nomenclature of antidepressant drugs, particularly those belonging to the class of tricyclic antidepressants.
Pharmacology
Aptazapine is a noradrenergic and specific serotonergic antidepressant (NaSSA), which means it increases the levels of norepinephrine and serotonin in the brain, thereby improving mood and relieving symptoms of depression. It is also a potent antihistamine, which may contribute to its sedative effects.
Related Terms
- Tricyclic antidepressant (TCA): A class of antidepressant drugs that are structurally related to the three-ring chemical structure of the original TCAs.
- Mianserin: A tetracyclic antidepressant that is structurally related to aptazapine and mirtazapine.
- Mirtazapine: A tetracyclic antidepressant that is structurally related to aptazapine and mianserin.
- Noradrenergic and specific serotonergic antidepressant (NaSSA): A class of antidepressant drugs that increase the levels of norepinephrine and serotonin in the brain.
- Norepinephrine: A neurotransmitter that is involved in regulating mood and anxiety.
- Serotonin: A neurotransmitter that is involved in regulating mood, appetite, and sleep.
- Antihistamine: A class of drugs that block the action of histamine, a chemical in the body that is involved in allergic reactions and in the regulation of physiological functions such as sleep and appetite.
External links
- Medical encyclopedia article on Aptazapine
- Wikipedia's article - Aptazapine
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