Mosapramine
Mosapramine is an atypical antipsychotic used in Japan for the treatment of schizophrenia. It was approved for use in 1991. Mosapramine acts as a D2 receptor antagonist and also has high affinity for the sigma receptors, possibly playing a role in its antipsychotic effects.
Pharmacology
Mosapramine is classified as an atypical antipsychotic due to its distinct pharmacology; it has a high affinity for the D2, D3, and D4 dopamine receptors, and also for the sigma receptors. The drug has a lower affinity for the serotonin 5-HT2A and 5-HT2C receptors.
Clinical Use
In Japan, mosapramine is used for the treatment of schizophrenia. It has been found to be effective in treating both positive and negative symptoms of the disorder. The drug is usually well-tolerated, with side effects similar to those of other atypical antipsychotics.
Side Effects
Common side effects of mosapramine include drowsiness, dizziness, and dry mouth. Less common side effects can include tachycardia, hypotension, and extrapyramidal symptoms such as tremor and akathisia. Rare but serious side effects can include neuroleptic malignant syndrome and tardive dyskinesia.
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