Norbinaltorphimine

Norbinaltorphimine (norBNI) is a kappa opioid receptor antagonist used in scientific research. It has a long duration of action, with effects lasting for up to several weeks after a single administration. This has made it a valuable tool in the study of the kappa opioid system, although its mechanism of action is not fully understood.

Pharmacology

Norbinaltorphimine is a selective antagonist for the kappa opioid receptor. It is able to block the effects of kappa opioid agonists, such as U-50488 and spiradoline. The duration of action of norbinaltorphimine is unusually long, with effects lasting for up to several weeks after a single administration. This is thought to be due to the drug slowly dissociating from the kappa opioid receptor.

Uses

Norbinaltorphimine is used primarily in scientific research to study the kappa opioid system. It has been used in studies investigating the role of the kappa opioid system in pain, mood disorders, drug addiction, and other conditions.

Side Effects

As a research tool, norbinaltorphimine is not typically used in humans, and so its side effect profile is not well known. However, as a kappa opioid antagonist, it may potentially cause symptoms such as anxiety, depression, and increased sensitivity to pain.

See Also

• Kappa opioid receptor
• U-50488
• Spiradoline

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  Structural formula of Norbinaltorphimine