Phenoxybenzamine

Phenoxybenzamine (pronounced: fen-ox-ee-BEN-za-meen) is a non-selective, irreversible alpha blocker used primarily in the treatment of pheochromocytoma. It is also used to treat hypertension, and given pre-operatively to prevent hypertension during surgery.

Etymology

The term "Phenoxybenzamine" is derived from its chemical structure, which consists of a phenoxy group attached to a benzene ring, and an amine group.

Usage

Phenoxybenzamine works by blocking alpha-1 and alpha-2 adrenergic receptors, thereby reducing the effects of catecholamines like epinephrine and norepinephrine. It is most commonly used to treat pheochromocytoma, a rare tumor of the adrenal gland which secretes excessive amounts of catecholamines.

Related Terms

Alpha blocker: A type of medication that reduces nerve impulses to blood vessels and muscles in the heart.
Pheochromocytoma: A rare tumor of the adrenal gland which secretes excessive amounts of catecholamines.
Hypertension: A condition characterized by consistently high blood pressure.
Epinephrine: A hormone and neurotransmitter also known as adrenaline.
Norepinephrine: A hormone and neurotransmitter also known as noradrenaline.

External links

Medical encyclopedia article on Phenoxybenzamine
Wikipedia's article - Phenoxybenzamine

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Phenoxybenzamine