Tricyclic
Tricyclic
Tricyclic (pronunciation: /ˈtraɪˌsaɪklɪk/) is a term used to describe a class of antidepressant drugs that are characterized by their three-ring chemical structure. The term is derived from the Greek words "tri" meaning three, and "kyklos" meaning circle or ring.
History
Tricyclic antidepressants (TCAs) were first introduced in the 1950s and were among the first effective treatments for depression. They have largely been replaced by newer antidepressants that have fewer side effects, but they are still used in certain cases where other treatments are ineffective.
Mechanism of Action
Tricyclics work by inhibiting the reuptake of certain neurotransmitters in the brain, specifically serotonin and norepinephrine. This increases the levels of these chemicals in the brain, which can help to alleviate symptoms of depression.
Examples
Some examples of tricyclic antidepressants include amitriptyline, nortriptyline, and imipramine. These drugs are also sometimes used to treat other conditions, such as chronic pain and certain types of anxiety disorders.
Side Effects
Common side effects of tricyclic antidepressants include dry mouth, blurred vision, constipation, and dizziness. They can also have more serious side effects, such as an increased risk of suicide in some individuals, particularly in the early stages of treatment.
Related Terms
- Antidepressant: A medication used to treat depression.
- Serotonin: A neurotransmitter that is involved in the regulation of mood, appetite, and sleep.
- Norepinephrine: A neurotransmitter that is involved in the regulation of attention and responding actions.
- Chronic Pain: Long-term pain that lasts for more than three months.
- Anxiety Disorders: A group of mental disorders characterized by significant feelings of anxiety and fear.
External links
- Medical encyclopedia article on Tricyclic
- Wikipedia's article - Tricyclic
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