N-Phenethyl-14-ethoxymetopon
N-Phenethyl-14-ethoxymetopon is a potent opioid analgesic drug that is structurally related to metopon and the morphinan family. It was developed by a team at the University of Alberta in the late 1990s.
Chemistry
N-Phenethyl-14-ethoxymetopon is a derivative of metopon, which itself is a derivative of hydromorphone. It is synthesized by replacing the N-methyl group of metopon with a phenethyl group, and the 14-hydroxy group with an ethoxy group. This modification results in a drug that is approximately 60 times more potent than morphine in its analgesic effects.
Pharmacology
Like other opioids, N-Phenethyl-14-ethoxymetopon acts on the mu opioid receptor to produce its analgesic effects. It is thought to be a full agonist at this receptor, meaning it can fully activate the receptor to produce its maximum possible response.
Clinical Use
Despite its potency, N-Phenethyl-14-ethoxymetopon is not currently used in clinical practice. Its development was primarily for research purposes, to better understand the structure-activity relationships of opioid drugs. However, its high potency and long duration of action suggest that it could potentially be useful in the treatment of severe chronic pain.
See Also
References
N-Phenethyl-14-ethoxymetopon
N-Phenethyl-14-ethoxymetopon structure
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Contributors: Prab R. Tumpati, MD
