Sequifenadine

Sequifenadine
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INN
Drug class
Routes of administration	Oral
Pregnancy category
Bioavailability
Metabolism
Elimination half-life
Excretion
Legal status
CAS Number	104478-77-9
PubChem	65959
DrugBank
ChemSpider	59363
KEGG

Sequifenadine is an antihistamine medication primarily used for the treatment of allergic rhinitis and other allergy-related symptoms. It is known for its ability to alleviate symptoms such as sneezing, itching, and runny nose by blocking the action of histamine, a substance in the body that causes allergic symptoms.

Pharmacology

Sequifenadine is classified as a second-generation antihistamine. Unlike first-generation antihistamines, it is less likely to cross the blood-brain barrier, which reduces the risk of sedation and drowsiness. This makes it a preferable option for patients who need to maintain alertness and cognitive function while managing allergy symptoms.

Mechanism of Action

Sequifenadine works by selectively inhibiting the H1 receptor, a type of histamine receptor found in various tissues throughout the body. By blocking these receptors, sequifenadine prevents histamine from exerting its effects, thereby reducing the symptoms associated with allergic reactions.

Pharmacokinetics

The pharmacokinetic profile of sequifenadine includes its absorption, distribution, metabolism, and excretion. It is typically administered orally, and its absorption can be influenced by factors such as food intake and gastrointestinal pH. The drug is metabolized in the liver and excreted primarily through the kidneys.

Clinical Use

Sequifenadine is indicated for the relief of symptoms associated with:

• Allergic rhinitis
• Urticaria (hives)
• Other allergic conditions

Dosage and Administration

The dosage of sequifenadine varies depending on the severity of the symptoms and the patient's response to the medication. It is important to follow the prescribing physician's instructions and not exceed the recommended dose.

Side Effects

Common side effects of sequifenadine may include:

• Headache
• Nausea
• Dry mouth

Serious side effects are rare but can include:

• Allergic reactions
• Heart palpitations

Contraindications

Sequifenadine should not be used in patients with known hypersensitivity to the drug or any of its components. Caution is advised in patients with renal impairment or hepatic impairment.

Interactions

Sequifenadine may interact with other medications, including:

• CYP3A4 inhibitors
• Other antihistamines

Patients should inform their healthcare provider of all medications they are taking to avoid potential interactions.

Research and Development

Ongoing research is exploring the potential of sequifenadine in treating other conditions related to histamine release and allergic responses. Studies are also investigating its long-term safety and efficacy.

Also see

• Antihistamine
• Allergic rhinitis
• Histamine receptor
• Second-generation antihistamines

First Generation Antihistamines

• Brompheniramine
• Carbinoxamine
• Chlorcyclizine
• Chlorpheniramine
• Clemastine
• Cyclizine
• Cyproheptadine
• Dexbrompheniramine
• Dexchlorpheniramine
• Dimenhydrinate
• Diphenhydramine
• Doxylamine
• Hydroxyzine
• Meclizine
• Phenyltoloxamine
• Promethazine
• Triprolidine

Second Generation Antihistamines

• Acrivastine
• Cetirizine
• Fexofenadine
• Levocetirizine
• Loratadine
• Desloratadine