Dizocilpine
Chemical compound
| Dizocilpine | |
|---|---|
| |
| INN | |
| Drug class | |
| Routes of administration | |
| Pregnancy category | |
| Bioavailability | |
| Metabolism | |
| Elimination half-life | |
| Excretion | |
| Legal status | |
| CAS Number | 77086-22-7 |
| PubChem | 3686 |
| DrugBank | DB01427 |
| ChemSpider | 3558 |
| KEGG | D07865 |
Dizocilpine, also known as MK-801, is a non-competitive antagonist of the NMDA receptor, a type of glutamate receptor in the central nervous system. It is known for its role in neuroscience research and has been used extensively to study the pathophysiology of neurodegenerative diseases and neuroprotection.
Mechanism of Action
Dizocilpine binds to the NMDA receptor at the phencyclidine (PCP) site, blocking the flow of calcium ions through the ion channel. This inhibition prevents the excitotoxicity that can result from excessive glutamate activity, which is implicated in various neurological disorders.
Research Applications
Dizocilpine is widely used in preclinical research to investigate the role of NMDA receptors in synaptic plasticity, learning, and memory. It has also been employed in studies of stroke, traumatic brain injury, and schizophrenia.
Side Effects and Toxicity
Due to its potent effects on the central nervous system, dizocilpine can cause significant neurotoxicity and behavioral changes in animal models. These effects limit its potential for therapeutic use in humans.
See Also
Dizocilpine
Dizocilpine
Dizocilpine with tube model
Transform your life with W8MD's budget GLP-1 injections from $125.
W8MD offers a medical weight loss program to lose weight in Philadelphia. Our physician-supervised medical weight loss provides:
- Most insurances accepted or discounted self-pay rates. We will obtain insurance prior authorizations if needed.
- Generic GLP1 weight loss injections from $125 for the starting dose.
- Also offer prescription weight loss medications including Phentermine, Qsymia, Diethylpropion, Contrave etc.
NYC weight loss doctor appointments
Start your NYC weight loss journey today at our NYC medical weight loss and Philadelphia medical weight loss clinics.
- Call 718-946-5500 to lose weight in NYC or for medical weight loss in Philadelphia 215-676-2334.
- Tags:NYC medical weight loss, Philadelphia lose weight Zepbound NYC, Budget GLP1 weight loss injections, Wegovy Philadelphia, Wegovy NYC, Philadelphia medical weight loss, Brookly weight loss and Wegovy NYC
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates, categories Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
