Levosulpiride
| Levosulpiride | |
|---|---|
| Levosulpiride.svg | |
| INN | |
| Drug class | |
| Routes of administration | Oral, Intramuscular, Intravenous |
| Pregnancy category | |
| Bioavailability | |
| Metabolism | |
| Elimination half-life | |
| Excretion | |
| Legal status | |
| CAS Number | 23672-07-3 |
| PubChem | 28860 |
| DrugBank | DB09210 |
| ChemSpider | 26834 |
| KEGG | D08110 |
Levosulpiride is an atypical antipsychotic and prokinetic agent used primarily in the treatment of schizophrenia, depression, and irritable bowel syndrome. It is the levo-enantiomer of sulpiride, which means it is a mirror image of the sulpiride molecule that has been isolated for its specific pharmacological effects.
Pharmacology[edit]
Levosulpiride acts as a selective antagonist of the dopamine D2 receptors, which are implicated in the pathophysiology of several psychiatric and gastrointestinal disorders. By blocking these receptors, levosulpiride helps to alleviate symptoms of psychosis and improve gastrointestinal motility.
Medical Uses[edit]
Levosulpiride is used in the management of:
Side Effects[edit]
Common side effects of levosulpiride include:
Mechanism of Action[edit]
Levosulpiride's primary mechanism of action is the antagonism of dopamine D2 receptors. This action is responsible for its antipsychotic and prokinetic effects. By inhibiting these receptors, levosulpiride can modulate neurotransmitter activity in the brain and enhance gastrointestinal motility.
Dosage and Administration[edit]
Levosulpiride is available in various forms, including oral tablets, intramuscular injections, and intravenous formulations. The dosage and administration depend on the condition being treated and the patient's response to the medication.
See Also[edit]
References[edit]
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