Dosulepin

Dosulepin, also known as dothiepin, is a tricyclic antidepressant (TCA) that is used in the treatment of depression. It is sold under several brand names, including Prothiaden, Dothep, Thaden and Dopress.

Pharmacology

Dosulepin is a potent inhibitor of serotonin and norepinephrine reuptake, leading to an increase in the concentration of these neurotransmitters in the synaptic cleft and therefore an enhancement of neurotransmission. It is also a potent blocker of histamine H1 receptors and muscarinic acetylcholine receptors, which accounts for its sedative and anticholinergic (drying) effects, respectively.

Clinical use

Dosulepin is used primarily in the treatment of depression, but is also used in the management of neuropathic pain and fibromyalgia. It has a similar efficacy to other TCAs and is generally well-tolerated.

Side effects

Common side effects of dosulepin include dry mouth, blurred vision, constipation, urinary retention, sweating, weight gain, and orthostatic hypotension. More serious side effects may include cardiac arrhythmias, seizures, and increased risk of suicide.

Contraindications

Dosulepin is contraindicated in individuals with known hypersensitivity to the drug, recent myocardial infarction, arrhythmias, and severe liver disease.

Interactions

Dosulepin may interact with other medications, including other antidepressants, antipsychotics, antihistamines, and anticholinergics, leading to an increased risk of side effects.

See also

• Tricyclic antidepressant
• Serotonin
• Norepinephrine
• Histamine H1 receptor
• Muscarinic acetylcholine receptor
• Neuropathic pain
• Fibromyalgia
• Orthostatic hypotension
• Cardiac arrhythmia
• Seizure
• Suicide
• Myocardial infarction

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Dosulepin

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  Chemical structure of Dosulepin

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  Crystal structure of Dosulepin hydrochloride