VUF-8430
VUF-8430
VUF-8430 is a chemical compound that acts as a selective agonist for the histamine receptor subtype H4. It is primarily used in scientific research to study the role of the H4 receptor in various physiological and pathological processes.
Chemical Properties
VUF-8430 is characterized by its specific chemical structure, which allows it to selectively bind to the H4 receptor. The compound's molecular formula and weight are crucial for its function as a receptor agonist. The structure of VUF-8430 is depicted in the image to the right.
Mechanism of Action
As an H4 receptor agonist, VUF-8430 mimics the action of histamine at this specific receptor subtype. The H4 receptor is primarily expressed in the immune system, including mast cells, eosinophils, and T cells. Activation of the H4 receptor by VUF-8430 can lead to various immune responses, making it a valuable tool for studying inflammation and allergic reactions.
Research Applications
VUF-8430 is used extensively in pharmacology and immunology research. It helps scientists understand the role of the H4 receptor in diseases such as asthma, allergic rhinitis, and autoimmune disorders. By studying the effects of VUF-8430, researchers can develop potential therapeutic strategies targeting the H4 receptor.
Related Compounds
Other compounds that interact with the H4 receptor include antagonists like JNJ-7777120 and A-940894. These compounds, along with VUF-8430, provide a comprehensive toolkit for exploring the pharmacological landscape of the H4 receptor.
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Contributors: Prab R. Tumpati, MD
