5-HT5A receptor

5-HT5A receptor is a protein that in humans is encoded by the HTR5A gene. It is a member of the 5-HT receptor family, which is a group of G protein-coupled receptors (GPCRs) that are targeted by a variety of psychoactive drugs. The 5-HT5A receptor is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen.

PBB GE HTR5A 221362 at tn

Function

The 5-HT5A receptor is expressed in various regions of the brain, and its role is still under investigation. However, it is known to play a role in learning and memory. It is thought to inhibit the release of the neurotransmitter dopamine and therefore could play a role in diseases such as schizophrenia.

Ligands

Several ligands have been discovered for the 5-HT5A receptor. Some of these include:

• Agonists: Lysergic acid diethylamide (LSD), 5-carboxamidotryptamine (5-CT)
• Antagonists: Risperidone, SB-699551

Clinical significance

The 5-HT5A receptor is thought to be involved in cognitive processes, making it a potential target for the treatment of cognitive disorders such as Alzheimer's disease. In addition, it may be involved in the pathophysiology of mood disorders, including depression and anxiety.

See also

• 5-HT receptor
• Serotonin receptor

References

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