Nipecotic acid
Nipecotic acid[edit]
Nipecotic acid is a chemical compound that is classified as a piperidine derivative. It is known for its role as a GABA reuptake inhibitor, which makes it of interest in the field of neuropharmacology.
Chemical properties[edit]
Nipecotic acid is a piperidine carboxylic acid, specifically a 3-piperidinecarboxylic acid. Its chemical formula is C6H11NO2, and it has a molecular weight of 129.16 g/mol. The structure of nipecotic acid includes a piperidine ring, which is a six-membered ring containing five carbon atoms and one nitrogen atom, with a carboxylic acid group attached.
Mechanism of action[edit]
Nipecotic acid functions primarily as a GABA reuptake inhibitor. It inhibits the reuptake of gamma-aminobutyric acid (GABA) into neurons and glial cells, thereby increasing the extracellular concentration of GABA in the central nervous system. This action enhances the inhibitory effects of GABA, which can lead to various therapeutic effects, particularly in the treatment of epilepsy and other neurological disorders.
Pharmacological effects[edit]
The inhibition of GABA reuptake by nipecotic acid results in increased GABAergic activity, which can have several effects:
- Anticonvulsant effects: By increasing GABA levels, nipecotic acid can help to stabilize neuronal activity and prevent seizures.
- Anxiolytic effects: Enhanced GABAergic transmission can also reduce anxiety, making nipecotic acid a potential candidate for the treatment of anxiety disorders.
Research and applications[edit]
Nipecotic acid has been studied for its potential use in treating epilepsy, anxiety disorders, and other conditions where enhanced GABAergic activity might be beneficial. However, its clinical use is limited due to its poor ability to cross the blood-brain barrier.
Related compounds[edit]
Nipecotic acid is structurally related to other GABA reuptake inhibitors, such as tiagabine, which is used clinically as an anticonvulsant. Research continues into developing analogs of nipecotic acid that might have improved pharmacokinetic properties.
Related pages[edit]
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