Acrivastine

Acrivastine

Chemical structure of Acrivastine

Acrivastine is a second-generation antihistamine used in the treatment of allergic rhinitis and urticaria. It is known for its rapid onset of action and is often combined with pseudoephedrine to enhance its effects in relieving nasal congestion.

Pharmacology

Acrivastine is a histamine H1 receptor antagonist, which means it works by blocking the action of histamine, a substance in the body that causes allergic symptoms. Unlike first-generation antihistamines, acrivastine has minimal sedative effects, making it suitable for daytime use.

Mechanism of Action

Acrivastine competes with histamine for binding at the H1 receptor sites on effector cells in the gastrointestinal tract, blood vessels, and respiratory tract. This prevents the typical allergic response, such as sneezing, itching, and runny nose.

Clinical Use

Acrivastine is primarily used to treat symptoms associated with seasonal allergic rhinitis and chronic idiopathic urticaria. It is effective in reducing symptoms such as sneezing, nasal congestion, and itchy eyes.

Dosage and Administration

Acrivastine is typically administered orally. The usual adult dose is 8 mg, taken up to three times a day. It is often available in combination with pseudoephedrine, marketed under various brand names.

Side Effects

Common side effects of acrivastine include headache, drowsiness, and dry mouth. Although it is less sedating than first-generation antihistamines, some patients may still experience drowsiness.

Contraindications

Acrivastine should not be used in individuals with known hypersensitivity to the drug or any of its components. Caution is advised in patients with renal impairment due to the drug's excretion through the kidneys.

Related Pages

• Antihistamine
• Allergic rhinitis
• Urticaria
• Histamine