Naloxegol
Naloxegol (pronounced: na-lox-eh-gol) is a peripherally acting mu-opioid receptor antagonist (PAMORA) used for the treatment of opioid-induced constipation (OIC) in adult patients with chronic non-cancer pain.
Etymology
The term "Naloxegol" is derived from its chemical structure, which is a derivative of naloxone, an opioid antagonist, and polyethylene glycol (PEG), a polymer used to increase the drug's size and restrict its ability to cross the blood-brain barrier.
Pharmacology
Naloxegol functions by blocking the mu-opioid receptors in the gastrointestinal tract, thereby reducing the constipating effects of opioids without affecting their analgesic effects in the central nervous system. This is due to its PEGylated structure, which prevents it from crossing the blood-brain barrier.
Usage
Naloxegol is administered orally once daily on an empty stomach, at least one hour prior to the first meal of the day or two hours after the meal. The recommended starting dose is 25 mg, but it may be reduced to 12.5 mg based on individual patient response.
Side Effects
Common side effects of naloxegol include abdominal pain, diarrhea, nausea, gas, vomiting, headache, and excessive sweating. Serious side effects may include opioid withdrawal symptoms and severe stomach pain or diarrhea.
Related Terms
External links
- Medical encyclopedia article on Naloxegol
- Wikipedia's article - Naloxegol
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