Tiospirone

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Tiospirone


Tiospirone is an atypical antipsychotic and anxiolytic that is used in the treatment of anxiety disorders. It is a serotonin receptor antagonist and dopamine receptor partial agonist. Tiospirone has been marketed in several countries, including Japan and Italy.

Pharmacology

Tiospirone acts as a serotonin 5-HT1A receptor partial agonist, and has strong affinity for the dopamine D2 receptors and dopamine D3 receptors. It also has affinity for the serotonin 5-HT2A receptor, serotonin 5-HT2C receptor, and serotonin 5-HT7 receptor. The drug has negligible affinity for the histamine H1 receptor and alpha-1 adrenergic receptor, and no significant affinity for the muscarinic acetylcholine receptors.

Clinical Use

Tiospirone is used primarily in the treatment of generalized anxiety disorder (GAD). It may also be used to treat other conditions as determined by a healthcare provider. The drug is typically taken orally, and dosage is adjusted based on the individual's response to treatment.

Side Effects

Common side effects of Tiospirone include dizziness, drowsiness, dry mouth, and nausea. Less common side effects may include changes in appetite, constipation, and blurred vision. In rare cases, Tiospirone may cause serious side effects such as irregular heartbeat, fainting, and mental/mood changes.

Interactions

Tiospirone may interact with other medications, including other antipsychotics, antidepressants, and benzodiazepines. It is important to inform your healthcare provider of all medications you are currently taking to avoid potential interactions.

See Also

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