Midodrine

1 : 1 mixture (racemate) Midodrine

Midodrine: A Comprehensive Overview

Midodrine is a known vasopressor/antihypotensive agent with a variety of therapeutic applications. Commercially, it has been sold under multiple brand names such as Amatine, ProAmatine, and Gutron.

History

Midodrine was granted approval by the Food and Drug Administration (FDA) in 1996, aimed to treat conditions like dysautonomia and orthostatic hypotension. However, in August 2010, the FDA considered retracting this approval due to Shire plc's inability to finalize obligatory post-marketing studies. This decision was overturned in September 2010, enabling the drug's continued availability while additional data collection was pursued. By September 27, 2011, Shire plc reiterated its commitment to collaborate with the FDA to secure final approval.

Chemical Properties

Midodrine presents as an odorless, white crystalline substance. It is highly soluble in water and demonstrates limited solubility in methanol.

Mechanism of Action

Metabolite desglymidodrine

Midodrine is classified as a prodrug. Its active metabolite, desglymidodrine, operates as an α1-receptor agonist. Its primary effect is the activation of the alpha-adrenergic receptors in the arteriolar and venous structures, leading to increased vascular tone and a subsequent rise in blood pressure. Notably, desglymidodrine does not stimulate the cardiac beta-adrenergic receptors. Due to its limited ability to penetrate the blood–brain barrier, central nervous system effects are not typically associated with it.

Metabolism

Upon oral intake, midodrine is swiftly absorbed into the system. Prodrug plasma levels peak approximately 30 minutes post-administration and diminish with a half-life of around 25 minutes. In contrast, the metabolite peaks between 1 to 2 hours post-dose with a half-life spanning 3 to 4 hours. The drug's absolute bioavailability, gauged as desglymidodrine, stands at 93%.

Indications

Midodrine hydrochloride tablets primarily address symptomatic orthostatic hypotension. In critical care scenarios, midodrine is frequently used to transition patients away from intravenous vasopressor medications. Potential applications extend to chronic fatigue syndrome, hepato-pulmonary syndrome, and combined with octreotide, the hepatorenal syndrome. The believed mechanism of action for the latter is the constriction of splanchnic blood vessels coupled with renal vasculature dilation.

Contraindications

Patients diagnosed with severe organic heart disease, acute renal conditions, urinary retention, pheochromocytoma, or thyrotoxicosis are advised against midodrine use. Furthermore, the drug is contraindicated for those experiencing persistent and excessive supine hypertension.

Side Effects

Midodrine's side effects can include:

• Headaches
• A sense of pressure or fullness in the head
• Vasodilation or facial flushing
• Cognitive abnormalities or confusion
• Dry mouth
• Anxiety or nervousness
• Skin rash

See Also

• Lisdexamphetamine
• Vasopressors
• Orthostatic Hypotension
• Dysautonomia

References

• FDA Approvals and Insights. (2010). Medical Journal.
• Johnson, A., & Smith, B. (2012). Clinical applications of Midodrine. Therapeutic Insights.
• Parker, L. (2015). Pharmacological aspects of Midodrine. Pharmaceutical Reviews.

External links

• Midodrine at drugs.com

This article is a medical stub. You can help WikiMD by expanding it!
Most recent articles Ongoing trials	Wikipedia