Primidolol

Primidolol

Chemical structure of Primidolol

Primidolol is a beta-adrenergic receptor antagonist (beta-blocker) that is used in the management of various cardiovascular conditions. It is a non-selective beta-blocker, meaning it inhibits both beta-1 and beta-2 adrenergic receptors. This medication is primarily used to treat hypertension, angina pectoris, and certain types of arrhythmias.

Mechanism of Action

Primidolol works by blocking the effects of epinephrine (adrenaline) and norepinephrine on beta-adrenergic receptors. By inhibiting these receptors, primidolol reduces the heart rate, decreases cardiac output, and lowers blood pressure. This action helps to alleviate the symptoms of angina and prevent arrhythmias by reducing the workload on the heart.

Pharmacokinetics

Primidolol is administered orally and is absorbed through the gastrointestinal tract. It undergoes hepatic metabolism and is excreted primarily through the kidneys. The half-life of primidolol allows for dosing once or twice daily, depending on the clinical scenario and patient response.

Clinical Uses

Primidolol is indicated for the treatment of:

• Hypertension: By lowering blood pressure, primidolol helps to reduce the risk of stroke and myocardial infarction.
• Angina pectoris: It decreases the frequency and severity of angina attacks by reducing myocardial oxygen demand.
• Arrhythmias: It is used in the management of certain types of arrhythmias by stabilizing cardiac electrical activity.

Side Effects

Common side effects of primidolol include:

• Bradycardia (slow heart rate)
• Hypotension (low blood pressure)
• Fatigue
• Dizziness
• Gastrointestinal disturbances

Less common but serious side effects may include:

• Bronchospasm, especially in patients with asthma or COPD
• Heart failure
• Depression

Contraindications

Primidolol should not be used in patients with:

• Asthma or severe chronic obstructive pulmonary disease (COPD)
• Bradycardia
• Heart block
• Cardiogenic shock

Related Pages

• Beta blocker
• Hypertension
• Angina pectoris
• Arrhythmia