Therapeutic testosterone
From WikiMD's medical encyclopedia
Therapeutic testosterone is a synthetic form of the endogenous androgenic steroid testosterone.
Mechanism of action of Therapeutic testosterone
In vivo, testosterone is irreversibly converted to dihydrotestosterone (DHT) in target tissues by the enzyme 5-alpha reductase. Testosterone or DHT ligand-androgen receptor complexes act as transcription factor complexes, stimulating the expression of various responsive genes. DHT binds with higher affinity to androgen receptors than testosterone, activating gene expression more efficiently. In addition, testosterone is irreversibly converted to estradiol by the enzyme complex aromatase, particularly in the liver and adipose tissue.
How does testosterone work?
Testosterone and DHT promote the development and maintenance of male sex characteristics related to the internal and external genitalia, skeletal muscle, and hair follicles; estradiol promotes epiphyseal maturation and bone mineralization.
Rapid metabolism
Due to rapid metabolism by the liver, therapeutic testosterone is generally administered as an ester derivative.
Clinical Trials Using Therapeutic testosterone
Check for ACTIVE CLINICAL TRIALS
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Categories:
- Pages with script errors
- Testosterone
- Cyclopentanols
- Alkene derivatives
- Androgens and anabolic steroids
- Androstanes
- Estrogens
- GABAA receptor positive allosteric modulators
- Hormones of the testis
- Hormones of the ovary
- Hormones of the hypothalamus-pituitary-gonad axis
- Hormones of the suprarenal cortex
- Enones
- Neuroendocrinology
- Human hormones
- Sex hormones
Contributors: Prab R. Tumpati, MD
