AC-262,536

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AC-262,356

AC-262,536 is a selective androgen receptor modulator (SARM) that has been studied for its potential applications in the treatment of conditions such as muscle wasting diseases, osteoporosis, and possibly the treatment of prostate cancer. As a SARM, AC-262,536 is designed to selectively target and activate androgen receptors in certain tissues, such as muscle and bone, while minimizing the activation of androgen receptors in other tissues, potentially reducing the risk of side effects associated with traditional anabolic steroids.

Mechanism of Action

AC-262,536 exerts its effects by binding to the androgen receptor (AR) with high affinity and selectivity. Unlike traditional anabolic steroids, which bind to androgen receptors in many tissues throughout the body, AC-262,536 is designed to preferentially activate the receptors in muscle and bone. This selective activation is intended to promote anabolic effects, such as muscle growth and bone density improvement, without the androgenic side effects typically associated with steroid use, such as prostate enlargement, hair loss, and the development of male characteristics in women.

Clinical Studies and Research

As of the last update, AC-262,536 has been primarily studied in preclinical settings, with limited information available from human clinical trials. Research in animal models has suggested that AC-262,536 can promote muscle growth and bone density without the full spectrum of androgenic effects. However, the extent of its efficacy and safety in humans remains to be fully determined through clinical research.

Potential Applications

The potential applications of AC-262,536 are broad, given its mechanism of action. It could be beneficial for individuals suffering from muscle wasting diseases, such as muscular dystrophy or cachexia associated with cancer, AIDS, and other chronic illnesses. Additionally, its ability to potentially increase bone density makes it a candidate for the treatment of osteoporosis and related conditions. There is also speculative interest in its use for the treatment of low testosterone levels in men, known as hypogonadism, and for the possible treatment of prostate cancer, by providing anabolic benefits without the adverse effects associated with traditional therapies.

Safety and Side Effects

The safety profile of AC-262,536 has not been fully established. In theory, by selectively targeting muscle and bone, AC-262,536 should have a reduced risk of the side effects associated with non-selective androgen receptor activators. However, without extensive human clinical trials, the potential adverse effects cannot be comprehensively assessed. Concerns typical of SARMs and anabolic agents, such as impacts on cardiovascular health, liver function, and hormone levels, would need to be thoroughly investigated.

Legal Status

The legal status of AC-262,536 varies by jurisdiction. It is important to note that as of the last update, AC-262,536 and other SARMs are often classified as research chemicals and are not approved for human use by regulatory agencies such as the Food and Drug Administration (FDA) in the United States. This status restricts their legal use to research settings, and they are not legally available as dietary supplements or medications for personal use.

Conclusion

AC-262,536 represents a promising area of research in the field of selective androgen receptor modulators, with potential applications in treating a variety of conditions related to muscle and bone health. However, the lack of comprehensive clinical data underscores the need for further research to fully understand its efficacy, safety, and potential role in medical therapy.

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Contributors: Prab R. Tumpati, MD