Dienestrol

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Dienestrol (pronounced: dye-EN-est-rol) is a synthetic, non-steroidal estrogen that was first synthesized in 1938. It is used in medicine for its estrogenic effects, such as in the treatment of menopausal symptoms and in hormone therapy for transgender women.

Etymology

The term "Dienestrol" is derived from the Greek words "diene" meaning "two double bonds" and "estrol" from the class of compounds known as estrogens.

Pharmacology

Dienestrol is a type of phenolic estrogen. It is similar in structure and function to other estrogens like estradiol and ethinylestradiol. It binds to the estrogen receptor and activates it, leading to an increase in the transcription of genes that are responsive to estrogens.

Medical Uses

Dienestrol is used in the treatment of menopausal symptoms such as hot flashes, vaginal dryness, and osteoporosis. It is also used in hormone therapy for transgender women.

Side Effects

Like other estrogens, Dienestrol can have side effects. These can include nausea, bloating, breast tenderness, and an increased risk of blood clots and stroke. It can also increase the risk of certain types of cancer, including breast cancer and endometrial cancer.

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