11-Deoxycorticosterone
11-Deoxycorticosterone (pronounced as eleven-deoxy-cortico-sterone) is a steroid hormone produced by the adrenal gland. It is also known as 21-hydroxyprogesterone and is a precursor of mineralocorticoids.
Etymology
The term 11-Deoxycorticosterone is derived from its chemical structure, which is a corticosteroid lacking an oxygen atom at the 11th carbon position. The prefix 'deoxy' is derived from Greek, meaning 'lacking oxygen'.
Function
11-Deoxycorticosterone is a corticosteroid and acts as a precursor in the biosynthesis of the hormone aldosterone. It has minimal glucocorticoid effects, but can have significant mineralocorticoid effects in humans.
Synthesis
The synthesis of 11-Deoxycorticosterone occurs in the adrenal cortex. It is synthesized from progesterone through the action of two enzymes: 21-hydroxylase and 11β-hydroxylase.
Clinical Significance
In humans, 11-Deoxycorticosterone has been shown to have a role in congenital adrenal hyperplasia, a group of inherited disorders affecting the adrenal glands. It is also used in the treatment of adrenal insufficiency and Addison's disease.
Related Terms
- Corticosteroid
- Adrenal gland
- Mineralocorticoid
- Aldosterone
- 21-hydroxylase
- 11β-hydroxylase
- Congenital adrenal hyperplasia
- Adrenal insufficiency
- Addison's disease
External links
- Medical encyclopedia article on 11-Deoxycorticosterone
- Wikipedia's article - 11-Deoxycorticosterone
This WikiMD dictionary article is a stub. You can help make it a full article.
Languages: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
Urdu,
বাংলা,
తెలుగు,
தமிழ்,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
European
español,
Deutsch,
français,
русский,
português do Brasil,
Italian,
polski